They may have special knowledge of other types of internal medicine and specialties, as well, and they work closely with other doctors to help make patients comfortable and improve their health. Pulmonologists diagnose, treat, and research pulmonary diseases and problems.
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![]() ![]() New features in the Windows release include the ability to create, open, edit, save, and share files in the cloud straight from the desktop, a new search tool for commands available in Word, PowerPoint, Excel, Outlook, Access, Visio and Project named "Tell Me", more "Send As" options in Word and PowerPoint, and co-authoring in real time with users connected to Office Online. It is the last version of Microsoft Office to support Windows 7 SP1, Windows Server 2008 R2 SP1, Windows 8, Windows Server 2012, Windows 8.1, Windows Server 2012 R2, Windows 10 RTM–1803 and Windows Server 2016 as the following version, Microsoft Office 2019 only supports Windows 10 version 1809, Windows Server 2019 or later. Office 2016 requires Windows 7 SP1, Windows Server 2008 R2 SP1 or OS X Yosemite at the minimum. The perpetually licensed version on macOS and Windows was released on September 22, 2015. Mainstream support ended on October 13, 2020, and extended support for most editions of Office 2016 will end on October 14, 2025, the same day as Windows 10. It was released on macOS on July 9, 2015, and on Microsoft Windows on September 22, 2015, for Office 365 subscribers. Microsoft Office 2016 (First perpetual release of Office 16) is a version of the Microsoft Office productivity suite, succeeding both Office 2013 and Office for Mac 2011 and preceding Office 2019, which in turn was succeeded by Office 2021 for both platforms. ![]() Proofing only (11): Hausa, Igbo, isiXhosa, isiZulu, Kinyarwanda, Pashto, Romansh, Sesotho sa Leboa, Setswana, Wolof, YorubaĮnglish, Arabic, Chinese (Simplified), Chinese (Traditional), Czech, Danish, Dutch, Finnish, French, German, Greek, Hebrew, Hungarian, Indonesian, Italian, Japanese, Korean, Norwegian (Bokmål), Polish, Portuguese (Portugal), Portuguese (Brazil), Russian, Slovak, Spanish, Swedish, Thai, Turkish. ![]() Partial (51): Afrikaans, Albanian, Amharic, Armenian, Assamese, Azerbaijani (Latin), Bangla (Bangladesh), Bangla (Bengali India), Basque (Basque), Belarusian, Bosnian (Latin), Catalan, Dari, Filipino, Galician, Georgian, Gujarati, Icelandic, Irish, Kannada, Khmer, KiSwahili, Konkani, Kyrgyz, Luxembourgish, Macedonian (FYROM Macedonia), Malayalam, Maltese, Maori, Marathi, Mongolian (Cyrillic), Nepali, Norwegian Nynorsk, Odia, Persian (Farsi), Punjabi (Gurmukhi), Quechua, Scottish Gaelic, Serbian (Cyrillic, Bosnia & Herzegovina), Serbian (Cyrillic, Serbia), Sindhi (Arabic), Sinhala, Tamil, Tatar (Cyrillic), Telugu, Turkmen (Latin), Urdu, Uyghur, Uzbek (Latin), Valencian, Welsh.Full (40): Arabic, Bulgarian, Chinese (Simplified), Chinese (Traditional), Croatian, Czech, Danish, Dutch, English, Estonian, Finnish, French, German, Greek, Hebrew, Hindi, Hungarian, Indonesian, Italian, Japanese, Kazakh, Korean, Latvian, Lithuanian, Malay (Latin), Norwegian Bokmål, Polish, Portuguese (Brazil), Portuguese (Portugal), Romanian, Russian, Serbian (Latin, Serbia), Slovak, Slovenian, Spanish, Swedish, Thai, Turkish, Ukrainian, Vietnamese. ![]() On a Mac with multiple displays, you can choose which one Monterey shows the AirPlay stream. Step 2: Now connect your Mac and iPhone to a similar Wi-Fi network. There are no options to turn it into a window. Step 1: After installing Reflector 3 on your Mac, run it. Compare Reflector 4 alternatives for your business. Reflector 2.6.0 Mac Torrent is the latest release version of the most advanced Screen mirroring features for Mac OS X that allows you turn you Mac into AirPlay.Reflector 2 Crack Mac enables you transfer files between these phones such as the iPhone, iPad, Touchpad and Crown with the computer. NET is open-sourced, ILSpy also works with Linux and Mac. You can disable that.īy contrast, Apple’s built-in Monterey AirPlay receiver always enters full-screen mode. Reflector 4 is available for Windows, Mac, iPhone, iPad, Android and Chromebook. 4 Answers Sorted by: 18 Since most of the parts of. Kick back and play any iOS game on your Mac’s screen. Enable an iPhone or iPad wrapper and more. Features Easily demo iOS apps on any Mac running OS X Lion using AirPlay Mirroring on iOS 5. In a nod to skeuomorphism-a digital design style mimicking real materials and textures-the display appears in a frame identical to the sending device. Reflector allows you to AirPlay mirror your iPhone or iPad to your Mac. You can opt for full-screen mode or disable the above-all-apps options. Reflector 4 is a screen mirroring and media streaming software tool geared toward companies and educational institutions. According to the results of the Google Safe Browsing check, the developer's site is safe. The program is categorized as Education Tools. We cannot confirm if there is a free download of this app available. When Reflector begins to show the received display, it appears by default in a floating window that hovers above all other windows. Description Downloading Reflector Teacher 3.2.1 for Mac from the developer's website was possible when we last checked. Consider your environment’s risk before making your choice-in most cases, you won’t need a code at all. You can change this behavior so that no code is needed, a password you set is used, a recurring code appears (the Onscreen Code option, the default), or a new code is generated each time. ![]() Select the Reflector name as a destination, and you’re prompted to enter an AirPlay confirmation code the code is shown on your Mac. Like most of the free movie streaming sites Rainierland hosts pirated content which is the reason why the main site is down most of the time. With minimal ads and pop-ups, users do like to use this streaming service for seamless streams. Rainierland is a free movie streaming website and is comparable to Putlocker. You can always look out for a Soap2day alternative in case you are not happy with a specific mirror.įrom TV classics to the latest theater hits, you will find it all on Soap2day. However, you will get used to them soon, because their extensive collection of content will keep you busy. It’s a great Putlocker alternative, known to provide a similar streaming experience.Īs a free site, Soap2day survives by supporting ads, so, you will have to deal with several pop-ups and banners. As a result, it gets one of the highest numbers of visitors. So, it brings all your favorite content under a single roof. It is also an excellent platform to stream films. But access to TV channels is not the only advantage of this site. Literally, you get ads on every click which is somewhat annoying.Īre you interested in accessing the best television shows for free? Then Soap2day is your destination. The only reason why users prefer any other movie streaming website over Couchtuner is the number of intrusive ads they have to tackle while streaming. A near-perfect interface and the overall availability of the website make it one of the best alternatives to Putlcoker. You must sign up on the site using an email id, but the sign-up is free.Ĭouchtuner is another popular movie streaming website that features all the latest movies and sitcoms in its arsenal. You will also find videos categorized by country name, which means that you’ll get to watch movies from different parts of the world, from India to Korea. ![]() But apart from those, the site is the perfect place to access movies and shows from all genres or categories. You’ll need to ignore the few ads, which is standard on websites like these. The interface is easy to use, and you’ll get one of the best platforms to stream videos with SolarMovie. ![]() ![]() You can access the wide collection of movies and shows on the site for an unlimited streaming experience. It’s free it’s fast, and it’s upgraded to give you the best. Looking for a platform that can provide you with a vast collection of videos for free? SolarMovie has the potential to be the best Putlocker for you. 4) What Are The Best Putlocker Alternatives? 17 Best Movie Streaming Sites Like Putlocker in 2023Īre you missing the collection of Putlockers movies and TV shows?Īre you desperately seeking some alternatives?Ĭheck out the list of our favorite sites. ![]() It also got high marks for ease of use and popularity. It got a perfect mark for pricing since it offers a free plan, affordable paid plans of less than $10 per user, and transparent pricing. With Clockify, your staff will simply need to type in the project name or task that they’ll work on and then click the start/stop button to record actual hours.Ĭlockify earned an overall score of 4.15 out of 5 in our evaluation. Its robust time tracking features for its free option and affordable paid plans made Clockify our top pick.Ĭlockify’s time tracking apps are different from Homebase and Deputy’s time clock tools, which require employees to clock in/out. You can even send invoices to bill clients for the hours that you and your team worked on projects. This is an excellent tool for employers and freelancers who need to monitor time on projects as it captures all non-billable and billable hours worked. Harvest: Best for small business owners and freelancers looking for free time tracking, invoicing, and expensing toolsĬlockify tracks hours for unlimited projects for an unlimited number of users for free.QuickBooks Time (formerly TSheets): Best for QuickBooks users who need to track billable hours and monitor the work hours of their hourly workforce.ClockShark: Best for midsize construction companies (fewer than 100 employees).busybusy: Best for independent contractors or construction business startups.TimeCamp: Best for employers, contractors, or freelancers looking for a lightweight project management tool.Homebase: Best for free work hour tracking in one physical location.Deputy: Best for seasonal businesses that keep employees on standby.Clockify: Best overall time tracking software for employers and freelancers.To find the best time tracking software for small businesses, we evaluated 20 solutions and narrowed it down to our top eight recommendations. Providers offering a free plan, a mobile app, and multiple clock-in options, among other features, were rated favorably. ![]() In this guide, we considered time tracking solutions for all those use cases. The best time tracking software for you depends on whether you’re looking to ensure accurate payroll for hourly staff, assign labor costs to jobs, or use employee hours to track projects and bill customers-or all of the above. ![]() A garment the same size as you is likely to feel tight. We measure the dimension of the garment, and you should consider what dimensions will fit best on you. Size: 6 Measurements: Waist, laid flat & doubled: 26" Inseam: 25" Length, waist to hem: 33" Our advice for a good fit: measure your clothing, not your body. hopefully you find something that works for. also, for your comment regarding "expecting perfection," keep in mind that no pant will be perfect. rolling down usually happens when leggings are too small, but if you are convinced you have the right size, i would just recommend trying out a different style of legging. February 2019 to Current25malx detroit tigers game results lulufanatic1 Searching the first 6 characters will give you the style (Align) and the length of the leggings (25”) and all the color possibilities. They have recently also been making several lengths of the align shorts in 4”, 6”, 8” and 10” inseams. Lululemon Base Pace high rise fleece running tight, $118 $118 at Lululemon Lululemon makes their Align leggings in 21”, 23”, 25”, 28” and 31” inseams. The leggings features the same four-way-stretch as Lululemon's Align leggings and run up to a size 20 in select colors. ![]() ![]() We highly recommend referring to their size chart … I wear a size 6 in lululemon, which is equivalent to a US size small. What is a size 6 in lululemon leggings NWT Lululemon Evergreen Track Pant Size 6 Retro Running Athletic Waterproof Rain C$100 C$128 Lululemon Jogger C$45 C$119 LULULEMON Studio Pant (Tall) Black Unlined C$50 C$138 Lululemon Run On Jogger (28") C$89 Lululemon Wunder Under High-Rise Tight *Snow Washed Ribbed 28" in Washed Luna C$85 C$139 Ready to Rulu High-Rise Cropped Jogger In Blacklululemon typically runs true to size (TTS). ![]() Personal assistant Pepper Potts places the original reactor inside a small glass showcase. In his home workshop, Stark builds a sleeker, more powerful version of his improvised armor suit as well as a more powerful arc reactor for it and his chest. Obadiah Stane, his father's old partner and the company's manager, advises Stark that this may ruin Stark Industries and his father's legacy. After being rescued by Rhodes, Stark returns home and announces that his company will cease manufacturing weapons. The armored Stark battles his way out of the cave to find the dying Yinsen, then burns the Ten Rings' weapons and flies away, crashing in the desert and destroying the suit. Yinsen sacrifices himself to divert them while the suit powers up. Although they keep the suit hidden almost to completion, the Ten Rings discover their hostages' intentions and attack the workshop. Stark and Yinsen secretly build a small, powerful electric generator called an arc reactor to power Stark's electromagnet and a prototype suit of powered armor to aid in their escape. Ten Rings leader Raza offers Stark freedom in exchange for building a Jericho missile for the group, but he and Yinsen believe that Raza will not keep his word. Yinsen, a fellow captive and doctor, implants an electromagnet into Stark's chest to keep the shrapnel shards that wounded him from reaching his heart and killing him. He is captured and imprisoned in a cave by a terrorist group called the Ten Rings. ![]() After the demonstration, his convoy is ambushed and Stark is critically wounded by a missile used by the attackers-one of his company's own. Tony Stark, who has inherited the defense contractor Stark Industries from his late father Howard Stark, is in war-torn Afghanistan with his friend and military liaison, Lieutenant Colonel James Rhodes, to demonstrate the new "Jericho" missile. Two sequels have been released: Iron Man 2 (2010) and Iron Man 3 (2013). In 2022, the film was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant". It was selected by the American Film Institute as one of the ten best films of 2008, received two nominations at the 81st Academy Awards for Best Sound Editing and Best Visual Effects. The film received praise from critics, especially for Downey's performance, as well as Favreau's direction, visual effects, action sequences, and writing. ![]() It grossed over $585 million, becoming the eighth-highest grossing film of 2008. Iron Man premiered in Sydney on April 14, 2008, and was released in the United States on May 2, being the first film in Phase One of the MCU. Rubber and metal versions of the armor, created by Stan Winston's company, were mixed with computer-generated imagery to create the title character. During filming, the actors were free to create their own dialogue because pre-production was focused on the story and action. Filming took place from March to June 2007, primarily in California to differentiate the film from numerous other superhero stories that are set in New York City-esque environments. Favreau signed on as director in April 2006, and faced opposition from Marvel when trying to cast Downey in the title role the actor was signed in September. Marvel put the project in production as its first self-financed film, with Paramount Pictures distributing. In the film, following his escape from captivity by a terrorist group, world-famous industrialist and master engineer Tony Stark builds a mechanized suit of armor and becomes the superhero Iron Man.Ī film featuring the character was in development at Universal Pictures, 20th Century Fox, and New Line Cinema at various times since 1990, before Marvel Studios reacquired the rights in 2005. as Tony Stark / Iron Man alongside Terrence Howard, Jeff Bridges, Gwyneth Paltrow, Leslie Bibb, and Shaun Toub. Directed by Jon Favreau from a screenplay by the writing teams of Mark Fergus and Hawk Ostby, and Art Marcum and Matt Holloway, the film stars Robert Downey Jr. Produced by Marvel Studios and distributed by Paramount Pictures, it is the first film in the Marvel Cinematic Universe (MCU). Iron Man is a 2008 American superhero film based on the Marvel Comics character of the same name. ![]() While these have produced a wealth of important information 8, 18, 19, 20, the lack of a system that replicates the essential features of human adaptive immunity, such as affinity maturation and class switching, and the effects of adjuvants, leaves many mechanistic aspects inaccessible. ![]() Almost all of these interactions have been elucidated through in vivo studies of inbred mice. ![]() Upon antigen presentation by antigen-presenting cells (APCs) 12, 13, 14, 15, T follicular helper (T FH) cells, and a variety of hematopoietic and non-hematopoietic cells interact and deliver signals to GC B cells for survival, proliferation, antibody affinity maturation, class-switch recombination and differentiation 16, 17. The B cells that are responsible for forming a neutralizing antibody response develop within germinal centers (GCs) and extrafollicular regions in lymphoid organs 8, 9, 10, 11. This system should prove useful for studying critical mechanisms underlying adaptive immunity in much greater depth than previously possible and to rapidly test vaccine candidates and adjuvants in an entirely human system.Īntigen recognition by lymphocytes has been studied by immunologists since the discovery of antibodies and their specificities over a century ago 1, 2, 3, 4, followed by the more recent discovery of T cells and their antigen receptors in the 1960s–1980s 5, 6, 7. We also show that it can be used to evaluate humoral immune responses to two priming antigens, rabies vaccine and an adenovirus-based severe acute respiratory syndrome coronavirus 2 vaccine, and to assess the effects of different adjuvants. We use this system to define the essential cellular components necessary to produce an influenza vaccine response. Here we use human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key germinal center features in vitro, including the production of antigen-specific antibodies, somatic hypermutation and affinity maturation, plasmablast differentiation and class-switch recombination. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. Nature Medicine volume 27, pages 125–135 ( 2021) Cite this article This new company raised $9.5 million in series A financing, led by ARCH Venture Partners, Canaan Partners and MD Anderson, with Rice University and Alexandria Real Estate Equities also participating.Modeling human adaptive immune responses with tonsil organoids In a separate arrangement made public in October, MD Anderson and Theraclone Sciences of Seattle formed OncoResponse, a firm that will rely on Theraclone's I-STAR immune repertoire screening technology to identify antibodies with exceptional reactivity from immune-oncology treated patients. The alliance will work on leukemia and myeloma, and the rare, incurable disease, blastic plasmacytoid dendritic cell neoplasma. In September, the center also entered an R&D alliance with Paris-based Cellectis to evaluate the biotech's allogeneic chimeric antigen receptor platform. The first clinical studies will start enrolling this year. Also in August, the MD Anderson Cancer Center agreed to collaborate with Merck of Kenilworth, New Jersey, to evaluate anti-PD-1 therapy, Keytruda (pembrolizumab) in combination with other medicines to treat hepatocellular and adenocarcinomas. This Houston-based spin-off begins operations with a hefty $60 million, two-thirds from the German parent company and the remainder from the Cancer Prevention and Research Institute of Texas. The biggest of these new ventures is its joint launch of Immatics US last August with Tubingen, Germany–based Immatics Biotechnologies. Houston-based MD Anderson Cancer Center has forged several new partnerships aimed at boosting its commercial prospects in the immune-oncology arena. ![]() and then to load document into editor, just call You might accomplish this like so: var js = ace.createEditSession("some js code") ![]() Session, store it in a var, and set the editor to another session (e.g. All other language modes are available as separate modules, loaded on demand like this: ("ace/mode/javascript") One Editor, Multiple SessionsĪce keeps everything about the state of the editor (selection, scroll position, etc.) ![]() Or use themelist extension to get the list of available themes at runtime.īy default, the editor supports plain text mode. Themes are loaded on demand all you have to do is pass the string name: tTheme("ace/theme/twilight") If you want editor to change it's size based on contents, use maxLines option as shown in Setting Themes ![]() If you resize the editor div in another manner, and need Ace to resize, use the following: editor.resize() Changing the size of the editorĪce only checks for changes of the size of it's container when window is resized. See Configuring-Ace wiki page for a more detailed list of options. some options are also available as methods e.g. use setOptions method to set several options at onceĮtOption("mergeUndoDeltas", "always") There are several ways to pass configuration to Ace // pass options to ace.edit In all of these examples Ace has been invokedĪs shown in the embedding guide. The packaged version can also be loaded from CDN's such as jsDelivr or cdnjs. One of src* subdirectories somewhere into your project, or use RequireJS to load the If you want to clone and host Ace locally you can Now check out the How-To Guide for instructions onĬommon operations, such as setting a different language mode or Var x = "All this is syntax highlighted" Į("ace/mode/javascript") Get prebuilt version of ace fromĪce-builds repository and use the code below: Both Cloud9 IDEĪce can be easily embedded into a web page. All these changes have been merged back to Ace Version of Skywriter's plugin system and some of Skywriter'sĮxtensibility points. In Berlin the Skywriter team decided to merge Ace with a simplified Mozilla Labs and was based on the tag, while Ace isĪnd uses the DOM for rendering. Git clone git:///ajaxorg/ace.git HistoryĪs two independent projects both aiming to build a no compromiseĬode editor component for the web. Take charge of your editor and add your favorite language Very simple and friendly to all kinds of projects, whether open-source We actively encourage and supportĬontributions! The Ace source code is hosted on GitHub
![]() Although BDG is inferior to CrAg LFA in regards to diagnosis of first-episode cryptococcal meningitis, potential applications include to use as a prognostic indicator for mortality, to monitor treatment response, and to help differentiate culture-positive relapse (i.e. BDG was found to rapidly decline with the start of antifungal therapy, falling ~50% after 4 days, unlike CrAg titers, which may continue to persist long after the completion of antifungal therapy. Detectable levels of BDG in CSF were found to correlate with quantitative fungal cultures, and BDG values of >500 pg/mL were associated with increased mortality. In this study, the Fungitell BDG assay (Associates of Cape Cod, Inc., Falmouth, Massachusetts) was found to have a sensitivity of 89% and a specificity of 85% as compared to the CrAg LFA. High levels of (1→3)-β-D-Glucan (BDG), for instance, were observed in the CSF of a recent cohort of Ugandan and South African HIV-infected patients with cryptococcal meningitis ( 19). In addition to these primary modalities available for diagnosing cryptococcal meningitis, non-specific markers of fungal infection should raise a concern for cryptococcosis in immune-compromised patients, and may play a useful role in prognosis and classification. However, performing CrAg titers can be labor intensive, requiring extra diluent, and increasing the cost. The use of India ink staining remains a common diagnostic tool for identifying Cryptococcus in cerebrospinal fluid (CSF), yet the sensitivity of India ink microscopy is only 1:1024 are associated with greater mortality at two and ten weeks ( 18). Diagnosis centers upon detection by microscopy, culture, or antigen. ![]() There are several modalities now available for the diagnosis of cryptococcal meningitis in HIV-infected persons ( 6). This review will focus on these innovations, providing an update in the field of cryptococcal diagnostics and management. Survivors can suffer from irreversible blindness and deafness, as well as reversible neurocognitive impairments ( 5).įortunately, several recent innovations in the screening, diagnosis, and management of cryptococcal meningitis have shown how to improve care for patients in resource-limited settings. In addition to high mortality, cryptococcal meningitis has substantial morbidity. Despite declines in long-term mortality from the introduction of antiretroviral therapy (ART)( 3), in low-income countries, ART distribution has not yet effectively reached all individuals needed to decrease the overall incidence of cryptococcal meningitis ( 4). In-hospital acute mortality from cryptococcal meningitis continues to remain high, ranging between 30-50%, even with antifungal therapy ( 2). New trials utilizing different combinations of antifungal therapy are reviewed, and we summarize the efficacy of different regimens.Ĭryptococcal meningitis remains a major cause of HIV-related mortality worldwide, with the largest burden of the disease in sub-Saharan Africa, South, and Southeast Asia ( 1). Fortunately, new approaches have been leading the way toward improving care for cryptococcal meningitis patients. Delaying ART initiation for 4 weeks after the diagnosis of cryptococcal meningitis is associated with improved survival. Controlling increased intracranial pressure with serial therapeutic lumbar punctures has a proven survival benefit. Optimal initial management with amphotericin and flucytosine improves survival against alternative therapies, although amphotericin is difficult to administer and flucytosine is not available in middle or low income countries, where cryptococcal meningitis is most prevalent. ![]() Targeted screening and treatment programs for cryptococcal antigenemia are a cost effective method for reducing early mortality on antiretroviral therapy (ART). Point of care testing has made diagnosing cryptococcal meningitis rapid, practical, and affordable. Recent advances in the diagnosis and management of cryptococcal meningitis are promising and have been improving long-term survival. |
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